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June 28, 2017

PhD Candidate Neerajha Nagarjan - "Biomechanical Investigation of Engineered Muscle Tissue Constructs for Disease Modeling and Biorobotics"

Contractility of heart muscle cells, or cardiomyocytes (CM), is the major parameter for determining their maturity and functionality. Consequently, investigating the effect of mechanical microenvironment on CM function is vital for understanding the underlying mechanism of their behavior in healthy as well as in diseased state. In this work, we investigated contractile biomechanical properties of cardiomyocytes using two different approaches, for biomedical applications ranging from biorobotics to heart disease studies

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June 28, 2017

Masters Candidate Hope Pearson - "BMP-2 Indirectly Induces Angiogenesis During Large Bone Defect Regeneration"

Critical-sized bone defects that do not heal without intervention have prolonged morbidity and are extremely costly. Additionally, their repair is often limited by insufficient neovascularization. Bone morphogenetic protein-2 (BMP-2) is used clinically to treat such defects and it has been proposed that BMP-2 is capable of directly inducing angiogenesis by signaling through endothelial cells. In addition, thrombopoietin (TPO) has been shown to stimulate bone healing through osteoblast activation by megakaryocytes, and has been implicated in angiogenesis.

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June 29, 2017

Masters Candidate Lisa Irimata - "An Anatomic Breast Phantom Mimicking Varying Levels of Radiographic Tissue Density for Investigating Contrast- Enhanced Detection of Microcalcifications"

Breast cancer is the most common form of cancer among women globally and the second leading cause of cancer-related deaths among women in the United States. Microcalcifications (┬Ácals) are the most commonly detected abnormality in the diagnosis of breast cancer. However, the detection of ┬Ácals and other breast lesions can be obscured by radiographically dense breast tissue.

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