Mechanobiology and Regenerative Medicine
Mechanosensory pathways in bone marrow
Marrow is a niche for progenitor cells for bone, cartilage, and the immune system. The wide array of cells present in marrow results in complex mechanobiological and biochemical signaling that affects cell proliferation and differentiation. A key focus of the Notre Dame Tissue Mechanics laboratory is studying the various mechanosensors in bone, and identifying their role in skeletal health using bioreactor culture systems along with cell culture and animal experiments. http://tml.ame.nd.edu.
The patterning of the embryo into multiple, correctly sized tissues depends on a complex "symphony" of signals that define cellular identities and growth. When subject to environmental or genetic insults, embryos exhibit a remarkable ability to repair mistakes, either by re-specification of gene expression or the elimination of cells through apoptosis (programmed cell death). We are utilizing quantitative imaging techniques, combined with genetic tools and computational modeling, to investigate the mechanism behind pattern repair in the Drosophila embryo. Uncovering the regenerative capabilities of embryonic tissues has the potential to lead to innovative approaches in tissue engineering and regenerative medicine. http://www3.nd.edu/~jzartman/